Thermodynamic Database for Protein-Nucleic Acid Interactions
نویسندگان
چکیده
Protein-nucleic acid interaction plays an essential role in the regulation of gene expression. Structural and binding information provides insight into the mechanism of protein-nucleic acid recognition. Although there are structural databases for protein-nucleic acid complexes, there exists no database for protein-nucleic acid binding. Thus, we have decided to develop the Thermodynamic Database for Protein-Nucleic Acid Interactions. It contains several important thermodynamic parameters, experimental conditions, structural information about proteins, nucleic acids and of the complex, and literature information. This database will be helpful for understanding the mechanism of proteinnucleic acid recognition. A WWW interface will help users to search the data based on various conditions with different sorting options for outputs.
منابع مشابه
Thermodynamic database for protein-nucleic acid interactions (ProNIT)
MOTIVATION Protein-nucleic acid interactions are fundamental to the regulation of gene expression. In order to elucidate the molecular mechanism of protein-nucleic acid recognition and analyze the gene regulation network, not only structural data but also quantitative binding data are necessary. Although there are structural databases for proteins and nucleic acids, there exists no database for...
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